Serotonergic System in the Central Nucleus of Amygdala Mediates Cannabidiol- Induced Sleep Alteration
نویسندگان
چکیده
منابع مشابه
Serotonergic System in the Central Nucleus of Amygdala Mediates Can- nabidiol-Induced Sleep Alteration
Cannabidiol (CBD) is one of the psycho-inactive constituents of marijuana, the Cannabis sativa. The pharmacological property of CBD, especially the anxiolytic effect, is significant in the therapeutic purposes. The central nucleus of amygdala (CeA) plays a key role in the anxiety and its related behavioral responses (e.g. sleep-wake activity), and serotonin is one of the major mediators. Howeve...
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Objective(s): Central nucleus of amygdala (CeA) is the most important region for morphine-induced reward, and GABAergic system plays an important role on morphine reinforcement. The influence of CeA administration of GABAB receptor agonist and antagonist on the expression and acquisition of morphine-induced incentive tolerance using conditioned place preference (CPP) paradigm was investigated i...
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The role of glutamate receptor within the nucleus accumbens in morphine tolerance has been postulated. Previous studies have reported that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study the effects of intra-accumbal injections of L-arginine (0.3, 1, and 3 ?g/rat), the NO precursor and L-NAME (0.3, 1, and 3 ?g/rat), the NOS inhibito...
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متن کاملInvolvement of nitric oxide within the rat central nucleus of amygdala in morphine tolerance
The role of glutamate receptor within the nucleus accumbens in morphine tolerance has been postulated. Previous studies have reported that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study the effects of intra-accumbal injections of L-arginine (0.3, 1, and 3 ?g/rat), the NO precursor and L-NAME (0.3, 1, and 3 ?g/rat), the NOS inhibito...
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ژورنال
عنوان ژورنال: The Open Sleep Journal
سال: 2008
ISSN: 1874-6209
DOI: 10.2174/1874620900801010058